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X-ray crystallography

Clicks:Updated:2015-08-24 15:08:20

X-ray crystallography is a tool used for identifying the atomic and molecular structure of a crystal,in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.By measuring the angles and intensities of these diffracted beams,a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal.From this electron density,the mean positions of the atoms in the crystal can be determined,as well as their chemical bonds,their disorder and various other information.

Since many materials can form crystals—such as salts,metals,minerals,semiconductors,as well as various inorganic,organic and biological molecules—X-ray crystallography has been fundamental in the development of many scientific fields.In its first decades of use,this method determined the size of atoms,the lengths and types of chemical bonds,and the atomic-scale differences among various materials,especially minerals and alloys.The method also revealed the structure and function of many biological molecules,including vitamins,drugs,proteins and nucleic acids such as DNA.X-ray crystallography is still the chief method for characterizing the atomic structure of new materials and in discerning materials that appear similar by other experiments.X-ray crystal structures can also account for unusual electronic or elastic properties of a material,shed light on chemical interactions and processes,or serve as the basis for designing pharmaceuticals against diseases.

In a single-crystal X-ray diffraction measurement,a crystal is mounted on a goniometer.The goniometer is used to position the crystal at selected orientations.The crystal is bombarded with a finely focused monochromatic beam of X-rays,producing a diffraction pattern of regularly spaced spots known as reflections.The two-dimensional images taken at different rotations are converted into a three-dimensional model of the density of electrons within the crystal using the mathematical method of Fourier transforms,combined with chemical data known for the sample.Poor resolution (fuzziness) or even errors may result if the crystals are too small,or not uniform enough in their internal makeup.

X-ray crystallography is related to several other methods for determining atomic structures.Similar diffraction patterns can be produced by scattering electrons or neutrons,which are likewise interpreted by Fourier transformation.If single crystals of sufficient size cannot be obtained,various other X-ray methods can be applied to obtain less detailed information; such methods include fiber diffraction,powder diffraction and (if the sample is not crystallized) small-angle X-ray scattering (SAXS).If the material under investigation is only available in the form of nanocrystalline powders or suffers from poor crystallinity,the methods of electron crystallography can be applied for determining the atomic structure.

For all above mentioned X-ray diffraction methods,the scattering is elastic; the scattered X-rays have the same wavelength as the incoming X-ray.By contrast,inelastic X-ray scattering methods are useful in studying excitations of the sample,rather than the distribution of its atoms.

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